Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed) | PAR 19 069

Opportunity Information: Apply for PAR 19 069

The National Institutes of Health (NIH), through the NIH Common Fund, is offering the Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed) under funding opportunity number PAR-19-069. This announcement is a reissue of PAR-18-733 and centers on the Gabriella Miller Kids First Pediatric Research Program (Kids First), a major effort to build and expand a pediatric research data resource that combines genome sequence information with detailed phenotype (clinical and trait) data. The resource is designed to serve researchers investigating the genetics of childhood cancers and structural birth defects by making high-quality, broadly shareable datasets available to the scientific community.

The main purpose of the program is to help scientists better understand the biological mechanisms that drive pediatric cancers and structural birth defects. By aggregating and harmonizing genomic and phenotypic data across many cohorts, Kids First aims to support discoveries that can improve diagnosis, refine disease classification, and ultimately contribute to more targeted therapies. A key theme of the opportunity is data sharing at scale: the program is explicitly structured to advance pediatric genetics research by enabling broad access to these integrated datasets rather than keeping data siloed within individual studies.

This particular funding opportunity supports small, focused research projects using the R03 mechanism. Projects are expected to be centered on developing and/or analyzing datasets related to childhood cancer and/or structural birth defects that are already part of the Kids First Data Resource, or that could be incorporated into it. In practical terms, applicants might propose targeted analyses that generate insights from existing Kids First datasets, work that improves the utility of a dataset for downstream research, or efforts that prepare additional relevant datasets for inclusion in the Kids First ecosystem. The announcement also allows proposals focused on developing statistical methods tailored to genome-wide analyses in these pediatric disease areas, recognizing that specialized analytic approaches are often needed for rare diseases, heterogeneous phenotypes, complex inheritance patterns, and the scale of modern genomic data.

The award is a grant with an announced ceiling of $200,000. The opportunity is categorized as discretionary and is tied to multiple CFDA numbers (93.121, 93.233, 93.273, 93.394, 93.395, 93.837, 93.838, 93.839, 93.865, 93.940), reflecting the cross-cutting nature of NIH support connected to genomics, child health, cancer research, and related biomedical domains. The original closing date listed for this posting is 2019-09-07, and the record shows a creation date of 2018-11-16.

Eligibility is broad and includes a wide range of organization types. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other unspecified eligible entities. The announcement also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions.

A crucial constraint is embedded in the title: Clinical Trial Not Allowed. That means applications should be limited to data-focused research and methods development rather than proposing prospective interventional studies that meet NIH definitions of a clinical trial. The intended scope is analytic and computational, leveraging the Kids First Data Resource and advancing its scientific value through rigorous analysis, dataset development, and appropriate statistical methodology for genome-scale pediatric research in cancer and structural birth defects.

• The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.233, 93.273, 93.394, 93.395, 93.837, 93.838, 93.839, 93.865, 93.940.
• This funding opportunity was created on 2018-11-16.
• Applicants must submit their applications by 2019-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $200,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 069

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