Opportunity Information: Apply for PAR 19 069
The National Institutes of Health (NIH), through the NIH Common Fund, is offering the Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed) under funding opportunity number PAR-19-069. This announcement is a reissue of PAR-18-733 and centers on the Gabriella Miller Kids First Pediatric Research Program (Kids First), a major effort to build and expand a pediatric research data resource that combines genome sequence information with detailed phenotype (clinical and trait) data. The resource is designed to serve researchers investigating the genetics of childhood cancers and structural birth defects by making high-quality, broadly shareable datasets available to the scientific community.
The main purpose of the program is to help scientists better understand the biological mechanisms that drive pediatric cancers and structural birth defects. By aggregating and harmonizing genomic and phenotypic data across many cohorts, Kids First aims to support discoveries that can improve diagnosis, refine disease classification, and ultimately contribute to more targeted therapies. A key theme of the opportunity is data sharing at scale: the program is explicitly structured to advance pediatric genetics research by enabling broad access to these integrated datasets rather than keeping data siloed within individual studies.
This particular funding opportunity supports small, focused research projects using the R03 mechanism. Projects are expected to be centered on developing and/or analyzing datasets related to childhood cancer and/or structural birth defects that are already part of the Kids First Data Resource, or that could be incorporated into it. In practical terms, applicants might propose targeted analyses that generate insights from existing Kids First datasets, work that improves the utility of a dataset for downstream research, or efforts that prepare additional relevant datasets for inclusion in the Kids First ecosystem. The announcement also allows proposals focused on developing statistical methods tailored to genome-wide analyses in these pediatric disease areas, recognizing that specialized analytic approaches are often needed for rare diseases, heterogeneous phenotypes, complex inheritance patterns, and the scale of modern genomic data.
The award is a grant with an announced ceiling of $200,000. The opportunity is categorized as discretionary and is tied to multiple CFDA numbers (93.121, 93.233, 93.273, 93.394, 93.395, 93.837, 93.838, 93.839, 93.865, 93.940), reflecting the cross-cutting nature of NIH support connected to genomics, child health, cancer research, and related biomedical domains. The original closing date listed for this posting is 2019-09-07, and the record shows a creation date of 2018-11-16.
Eligibility is broad and includes a wide range of organization types. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other unspecified eligible entities. The announcement also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions.
A crucial constraint is embedded in the title: Clinical Trial Not Allowed. That means applications should be limited to data-focused research and methods development rather than proposing prospective interventional studies that meet NIH definitions of a clinical trial. The intended scope is analytic and computational, leveraging the Kids First Data Resource and advancing its scientific value through rigorous analysis, dataset development, and appropriate statistical methodology for genome-scale pediatric research in cancer and structural birth defects.Apply for PAR 19 069
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.233, 93.273, 93.394, 93.395, 93.837, 93.838, 93.839, 93.865, 93.940.
- This funding opportunity was created on 2018-11-16.
- Applicants must submit their applications by 2019-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed).
What is the funding opportunity number (FOA)?
The FOA number is PAR-19-069.
Is this announcement new or a reissue of an earlier FOA?
This announcement is a reissue of PAR-18-733.
Which agency is offering this grant?
The grant is offered by the National Institutes of Health (NIH) through the NIH Common Fund.
What program or initiative does this opportunity support?
It supports the Gabriella Miller Kids First Pediatric Research Program (Kids First), which is focused on building and expanding a pediatric research data resource that integrates genomic and phenotypic data.
What is the Kids First Data Resource?
The Kids First Data Resource is a pediatric research data resource designed to combine genome sequence information with detailed phenotype data (clinical and trait data) and make high-quality datasets broadly shareable for the research community.
What diseases or research areas are the focus of Kids First?
The resource is designed to serve researchers studying the genetics of childhood cancers and structural birth defects.
What is the main purpose of the program behind this FOA?
The main purpose is to help scientists better understand the biological mechanisms driving pediatric cancers and structural birth defects by aggregating and harmonizing genomic and phenotypic data across many cohorts to support discoveries that can improve diagnosis and disease classification and contribute to more targeted therapies.
What type of grant mechanism is being used?
This FOA uses the R03 mechanism, supporting small, focused research projects.
What kinds of projects does this FOA support?
Projects are expected to focus on developing and/or analyzing datasets related to childhood cancer and/or structural birth defects that are already part of the Kids First Data Resource or that could be incorporated into it. The FOA also allows projects focused on developing statistical methods tailored to genome-wide analyses in these pediatric disease areas.
Do proposed datasets need to be part of Kids First already?
Projects may be centered on datasets that are already in the Kids First Data Resource or on datasets that could be incorporated into the Kids First ecosystem.
What does "Clinical Trial Not Allowed" mean for applicants?
It means applications should be limited to data-focused research, dataset development, analytic work, and methods development, and should not propose prospective interventional studies that meet the NIH definition of a clinical trial.
Is the emphasis more on generating new data or analyzing and improving existing data resources?
The emphasis is on leveraging and advancing the scientific value of integrated genomic and phenotypic datasets through rigorous analysis, improving dataset utility for downstream research, and preparing relevant datasets for inclusion in the Kids First Data Resource.
Why is data sharing an important theme in this opportunity?
Kids First is explicitly structured to advance pediatric genetics research by enabling broad access to integrated datasets at scale, rather than keeping data siloed within individual studies.
What is the maximum award amount (ceiling) for this grant?
The announced ceiling is $200,000.
What is the type of funding category listed for this opportunity?
The opportunity is categorized as discretionary.
Which CFDA numbers are associated with this opportunity?
This opportunity is tied to multiple CFDA numbers: 93.121, 93.233, 93.273, 93.394, 93.395, 93.837, 93.838, 93.839, 93.865, and 93.940.
What does it mean that multiple CFDA numbers are listed?
It reflects the cross-cutting nature of NIH support connected to genomics, child health, cancer research, and related biomedical domains, as described in the opportunity summary.
When was this opportunity record created?
The record shows a creation date of 2018-11-16.
What is the closing date listed in the posting?
The original closing date listed for this posting is 2019-09-07.
Who is eligible to apply?
Eligibility is broad and includes many organization types, such as state/county/local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations (other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other unspecified eligible entities.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement explicitly highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs.
Are faith-based or community-based organizations eligible to apply?
Yes. The eligibility list explicitly includes faith-based or community-based organizations.
Can federal agencies apply?
Yes. The announcement lists eligible federal agencies among the highlighted eligible applicant categories.
Are foreign (non-U.S.) organizations eligible?
Yes. The opportunity explicitly includes non-domestic (non-U.S.) entities (foreign organizations) as eligible applicants.
Are U.S. territories or possessions included in eligibility?
Yes. The announcement explicitly includes U.S. territories or possessions.
Are tribal entities eligible even if they are not federally recognized?
Yes. In addition to federally recognized tribal governments, the eligibility description includes Native American tribal organizations (other than federally recognized tribal governments) and explicitly highlights Indian/Native American tribal governments other than federally recognized entities.
What types of scientific work are explicitly encouraged?
The FOA supports targeted analyses that generate insights from existing Kids First datasets, work that improves the utility of datasets for downstream research, efforts that prepare additional relevant datasets for inclusion in Kids First, and development of statistical methods tailored to genome-wide analyses in pediatric cancers and structural birth defects.
Why does the FOA mention specialized statistical methods?
Because pediatric cancers and structural birth defects can involve rare diseases, heterogeneous phenotypes, complex inheritance patterns, and genome-scale data, which often require specialized analytic approaches.
What is the intended research scope overall?
The intended scope is analytic and computational, leveraging the Kids First Data Resource and advancing its scientific value through rigorous analysis, dataset development, and appropriate statistical methodology focused on pediatric cancer and structural birth defects.
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| Mentored Research Scientist Development Award (Parent K01 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 084 Funding Number: PA 19 084 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Technology Research Sites (UH2/UH3 Clinical Trial Optional) Apply for RFA AR 19 028 Funding Number: RFA AR 19 028 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program: Mechanistic Research Centers (U19 Clinical Trial Optional) Apply for RFA AR 19 026 Funding Number: RFA AR 19 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center (U24 Clinical Trial Not Allowed) Apply for RFA AR 19 027 Funding Number: RFA AR 19 027 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $3,600,000 |
| HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional) Apply for RFA NS 19 018 Funding Number: RFA NS 19 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 19 004 Funding Number: RFA AT 19 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA TR 19 003 Funding Number: RFA TR 19 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) (UG3/UH3 Clinical Trial Required) Apply for RFA DA 19 035 Funding Number: RFA DA 19 035 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) Apply for RFA AT 19 006 Funding Number: RFA AT 19 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 19 127 Funding Number: PA 19 127 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed) Apply for PA 19 124 Funding Number: PA 19 124 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
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