Opportunity Information: Apply for RFA AI 20 043
The Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed) funding opportunity (RFA-AI-20-043) is a National Institutes of Health cooperative agreement designed to build and operate a centralized immunologic reagent resource that strengthens the use of nonhuman primate (NHP) models across a range of biomedical research areas. The core purpose is to remove practical bottlenecks that slow NHP-based studies by ensuring that the research community has reliable access to high-quality immune reagents that actually work well in NHP systems, particularly in situations where suitable products are not available commercially or exist but have not been optimized or validated for NHP use.
The scientific scope centers on immunologic reagents that enable NHP research in vaccine and adjuvant development, transplantation, and both infectious and immune-mediated diseases. In practice, this means the funded resource is expected to identify what reagents are missing or inadequate for NHP work, obtain or generate candidate tools, and then put them through appropriate characterization and performance testing to confirm cross-reactivity with NHP cells or proteins and to document the conditions under which they function best. The emphasis is not only on development, but also on evaluation and standardization so that investigators can trust that the reagents behave consistently and can be compared across studies and sites. After validation, the program supports production and distribution to the wider scientific community, positioning the awardee as a supplier and steward of these tools rather than a single-lab developer.
A major deliverable is an openly accessible public website that includes a searchable database of immunologic reagents relevant to NHP research. Importantly, the database is intended to cover both commercial and non-commercial reagents and to focus on practical usability: which reagents cross-react with NHP targets, what species or tissues they have been tested in, how they perform in specific assay formats, and other information that helps researchers select the right tool without repeating trial-and-error experiments. By making this information centralized and searchable, the resource is meant to reduce duplication, improve reproducibility, and speed up experimental planning, especially for groups that do not have the time or budget to extensively screen human-targeted reagents for NHP compatibility.
From a funding and administrative standpoint, this opportunity is issued by the U.S. Department of Health and Human Services through NIH, using a cooperative agreement mechanism (U24). A cooperative agreement typically signals substantial programmatic involvement from NIH staff compared to a standard grant, reflecting that NIH expects to work closely with the awardee on priorities, deliverables, and coordination with the broader NHP research ecosystem. The FOA is explicitly labeled "Clinical Trial Not Allowed," meaning it is focused on tool and resource development rather than conducting clinical trial activities. The activity category is Health and the CFDA number associated with the program is 93.855. The opportunity anticipated making a single award (ExpectedAwards: 1). The posting lists an award ceiling of 0, which usually indicates that the ceiling was not specified in the summarized data field rather than implying no funding.
Eligibility is broad and includes many organization types that could credibly run a national-scale resource: state, county, and local governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses); Native American tribal governments and tribal organizations; public housing authorities/Indian housing authorities; independent school districts; and other applicants as allowed by the full eligibility language. The original posting date is June 29, 2020, with an original closing date of November 19, 2020.
Overall, the opportunity is aimed at building shared infrastructure for the immunology and infectious disease research community that relies on NHP models. By developing, validating, producing, distributing, and cataloging NHP-appropriate immunologic reagents, the program is intended to accelerate progress toward vaccines, treatments, and cures for immune-mediated conditions and emerging or reemerging infectious diseases, while also improving standardization and transparency in how NHP immunologic tools are selected and used.Apply for RFA AI 20 043
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Nonhuman Primate Reagent Resource (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
- This funding opportunity was created on Jun 29, 2020.
- Applicants must submit their applications by Nov 19, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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