NINDS Program Project Grant (P01) - Clinical Trial Optional | PAR 18 421

Opportunity Information: Apply for PAR 18 421

The NINDS Program Project Grant (P01) - Clinical Trial Optional (Funding Opportunity Number PAR-18-421) is a National Institutes of Health (NIH) discretionary grant mechanism run by the National Institute of Neurological Disorders and Stroke (NINDS). It supports large, coordinated research programs in neurological disorders and stroke that tackle important, mission-relevant scientific problems through a deliberately collaborative structure. The central idea is to fund a set of interdependent research projects that are tightly connected by a unifying theme, where the projects inform and strengthen one another in ways that would be difficult to accomplish if each project were funded as a separate stand-alone grant. While clinical trials are not required, they are allowed under this announcement, meaning applicants can propose clinical trial work if it fits the program and NIH rules.

This FOA is aimed at encouraging innovative, interactive research that comes from a synergistic partnership among strong investigators, including teams that may not typically work together. A key expectation is that the overall program is more than just a collection of related studies: the component projects should be designed so that progress in one area directly enables or accelerates progress in another, producing scientific advantages from the coordinated approach. In practice, that means the application should make a clear case that the program’s combined design, shared resources, and cross-project integration will answer major questions in neuroscience more effectively than multiple independent awards could.

Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants listed for this opportunity include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.

Foreign participation is limited in a way that often matters for multi-project programs. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant can include certain clearly justified, well-defined elements of the work that occur outside the United States, subject to NIH’s policies and approvals.

From the listing details provided, this opportunity falls under the NIH health research funding category and is associated with CFDA number 93.853. The FOA was created on 2017-11-29, and the original closing date shown is 2021-04-05. No award ceiling or expected number of awards is specified in the provided source data. Overall, the opportunity is best suited for research leaders who can build a coherent, multi-project neuroscience program with strong scientific integration, clear advantages from shared effort, and a persuasive rationale that the team-based structure is essential to achieving the program’s goals.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Program Project Grant (P01) - Clinical Trial Optional" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
• This funding opportunity was created on 2017-11-29.
• Applicants must submit their applications by 2021-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 18 421

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