Opportunity Information: Apply for PAR 18 421
The NINDS Program Project Grant (P01) - Clinical Trial Optional (Funding Opportunity Number PAR-18-421) is a National Institutes of Health (NIH) discretionary grant mechanism run by the National Institute of Neurological Disorders and Stroke (NINDS). It supports large, coordinated research programs in neurological disorders and stroke that tackle important, mission-relevant scientific problems through a deliberately collaborative structure. The central idea is to fund a set of interdependent research projects that are tightly connected by a unifying theme, where the projects inform and strengthen one another in ways that would be difficult to accomplish if each project were funded as a separate stand-alone grant. While clinical trials are not required, they are allowed under this announcement, meaning applicants can propose clinical trial work if it fits the program and NIH rules.
This FOA is aimed at encouraging innovative, interactive research that comes from a synergistic partnership among strong investigators, including teams that may not typically work together. A key expectation is that the overall program is more than just a collection of related studies: the component projects should be designed so that progress in one area directly enables or accelerates progress in another, producing scientific advantages from the coordinated approach. In practice, that means the application should make a clear case that the program’s combined design, shared resources, and cross-project integration will answer major questions in neuroscience more effectively than multiple independent awards could.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants listed for this opportunity include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
Foreign participation is limited in a way that often matters for multi-project programs. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components” are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant can include certain clearly justified, well-defined elements of the work that occur outside the United States, subject to NIH’s policies and approvals.
From the listing details provided, this opportunity falls under the NIH health research funding category and is associated with CFDA number 93.853. The FOA was created on 2017-11-29, and the original closing date shown is 2021-04-05. No award ceiling or expected number of awards is specified in the provided source data. Overall, the opportunity is best suited for research leaders who can build a coherent, multi-project neuroscience program with strong scientific integration, clear advantages from shared effort, and a persuasive rationale that the team-based structure is essential to achieving the program’s goals.Apply for PAR 18 421
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NINDS Program Project Grant (P01) - Clinical Trial Optional" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
- This funding opportunity was created on 2017-11-29.
- Applicants must submit their applications by 2021-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NINDS Program Project Grant (P01) - Clinical Trial Optional (PAR-18-421)
What is the NINDS Program Project Grant (P01) - Clinical Trial Optional (PAR-18-421)?
This is an NIH discretionary grant funding opportunity administered by the National Institute of Neurological Disorders and Stroke (NINDS). It supports large, coordinated research programs in neurological disorders and stroke that address important, mission-relevant scientific problems through a deliberately collaborative, multi-project structure.
What is the main purpose of a P01 program under this announcement?
The purpose is to fund a set of interdependent research projects organized around a unifying theme. The projects are expected to be tightly connected and designed so that findings, methods, or progress in one project directly informs and strengthens other projects, creating scientific advantages that would be difficult to achieve through separate stand-alone awards.
Is this grant intended for a single research project or multiple projects?
It is intended for multiple projects that are interdependent and coordinated as part of one overall program. The structure is specifically described as a set of projects connected by a unifying theme and designed to work together.
What does NINDS mean by a "deliberately collaborative structure"?
Based on the information provided, it means the program should be intentionally designed for collaboration and integration across component projects. The combined design, shared resources, and cross-project interactions should produce benefits that cannot be easily replicated if each project were pursued independently.
How is this different from submitting several related but independent grant applications?
The expectation is that the overall program is more than a collection of related studies. The application should clearly explain why the coordinated approach is essential, and how the projects will synergize so that the whole program is more impactful than multiple independent awards.
Are clinical trials required under this funding opportunity?
No. Clinical trials are not required.
Are clinical trials allowed under this funding opportunity?
Yes. The FOA is "clinical trial optional," meaning applicants may propose clinical trial work if it fits the program goals and complies with NIH rules.
What kind of research areas does this FOA support?
It supports research programs in neurological disorders and stroke that tackle important, NINDS mission-relevant scientific problems, within the broader NIH health research funding category.
What is meant by a "unifying theme" in the application?
The unifying theme is the central scientific focus that ties the component projects together. The component projects should be linked in a way that they collectively address major questions more effectively through integration than they would as separate efforts.
What does "synergy" mean in the context of this program project grant?
Synergy refers to the scientific advantage gained when progress in one project enables or accelerates progress in another. The program should be structured so that cross-project integration, shared resources, and coordinated design produce outcomes greater than the sum of individual projects.
Who is the administering agency for this opportunity?
The funding opportunity is run by the National Institutes of Health (NIH) through the National Institute of Neurological Disorders and Stroke (NINDS).
What is the Funding Opportunity Number (FOA number)?
PAR-18-421.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities. Eligible applicants listed include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Native American tribal organizations (other than federally recognized tribal governments)
- Public housing authorities / Indian housing authorities
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations (other than small businesses)
- Small businesses
Does the FOA highlight any additional eligible applicant categories?
Yes. It explicitly highlights additional eligible applicant categories such as:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- Indian/Native American tribal governments other than federally recognized
- U.S. territories or possessions
Can a foreign (non-U.S.) organization apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization.
Can a non-U.S. component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant.
Are any international activities allowed within an application?
Yes. "Foreign components" are allowed as defined in the NIH Grants Policy Statement. This generally means a U.S.-based applicant may include clearly justified, well-defined elements of work that occur outside the United States, subject to NIH policies and approvals.
What is the CFDA number associated with this opportunity?
CFDA 93.853.
When was this FOA created?
The FOA was created on 2017-11-29.
What is the original closing date shown for this opportunity?
The original closing date shown is 2021-04-05.
Is an award ceiling specified in the provided information?
No. The provided source data does not specify an award ceiling.
Is the expected number of awards listed in the provided information?
No. The provided source data does not specify the expected number of awards.
Who is this opportunity best suited for?
It is best suited for research leaders who can build a coherent, multi-project neuroscience program with strong scientific integration, clear advantages from shared effort, and a persuasive rationale that the team-based structure is essential to achieving the program's goals.
What is a key expectation reviewers may look for based on the description?
A key expectation is that the program is interactive and synergistic, not simply a set of related studies. The application should make a clear case that the coordinated approach, shared resources, and cross-project integration will answer major scientific questions more effectively than separate independent awards.
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