Opportunity Information: Apply for RFA NS 22 048
The BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Mouse Brain (UM1 Clinical Trial Not Allowed) funding opportunity (RFA-NS-22-048) is a National Institutes of Health (NIH) cooperative agreement designed to build large, integrated research centers focused on creating next-generation methods for mapping how the mouse brain is wired. The central aim is not simply to generate more data, but to develop and validate end-to-end technologies and workflows that can realistically scale up to brain-wide connectivity atlases. In practical terms, NIH is looking for centers that can prove they can map neuron-to-neuron connections at very fine detail, reaching at least synaptic-level resolution, while also demonstrating that the approach can be expanded beyond a small pilot region toward comprehensive, whole-brain applications.
A major emphasis of this FOA is building complete pipelines that cover data collection, data processing and analysis, and data sharing in a way that the broader neuroscience community can use. Applicants are expected to establish robust, repeatable workflows that show feasibility and quality at scale, rather than one-off demonstrations. The centers should be able to acquire connectivity data from mouse brain tissue, process and analyze it to extract cell-to-cell wiring information, and disseminate those results along with the associated tools, standards, and documentation needed for other researchers to interpret and reuse the outputs. Because this is a cooperative agreement (UM1), awardees should expect substantial coordination with NIH program staff and active participation in broader network activities, milestones, and shared objectives.
While the long-term vision is brain-wide wiring diagrams, the FOA also requires each center to demonstrate scientific value in a concrete way by focusing on a specific central nervous system (CNS) sub-volume. Within that selected brain region, centers are expected to test explicit hypotheses linking circuit structure to circuit function. That requirement is important: the program is not only about producing maps, but about showing that these maps can answer meaningful neuroscience questions, and that the technological approach generates insights that justify scaling it up.
Another key piece is interoperability and integration across scales and modalities. These centers are expected to include toolsets and infrastructure that can combine connectivity data collected separately in smaller volumes and merge or relate it to other kinds of neuroscience datasets. That could include integration across different imaging approaches, tracing methods, molecular or cell-type annotations, or other complementary modalities that help interpret connectivity in biological context. Just as importantly, the FOA stresses community interaction: the data products should not sit in a silo. Centers are expected to enable other scientists to explore, query, and mine the resulting datasets, supporting new questions beyond those originally posed by the center itself.
Awardees funded under this announcement will become part of the coordinated BRAIN CONNECTS Network, alongside projects funded through companion announcements. The network structure reflects NIHs intent to drive standardization, shared benchmarks, compatible data formats, and complementary coverage across projects, with the collective goal of producing wiring diagrams that span entire brains across multiple spatial scales. In other words, an individual center is expected to be excellent on its own, but also to function as a contributing node in a larger, coordinated national effort.
Administratively, this opportunity is categorized as discretionary funding using the cooperative agreement mechanism. The activity category listed for the opportunity is Education, Health, Income Security and Social Services, and the CFDA numbers associated with NIH neuroscience and related programs are provided (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867). The FOA specifies UM1 Clinical Trial Not Allowed, meaning the proposed work must not include clinical trials; the program is focused on mouse brain connectivity and enabling technologies rather than human interventional studies.
Eligibility is broad and includes many common applicant types such as public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district), along with independent school districts and public housing authorities/Indian housing authorities. It also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), tribal governments and organizations (including those other than federally recognized in the list provided), U.S. territories or possessions, regional organizations, eligible federal agencies, faith-based or community-based organizations, and even non-U.S. entities (foreign organizations). The original closing date listed in the source information is 2023-06-13, and the opportunity was created on 2022-02-22. The award ceiling and expected number of awards are not specified in the provided source excerpt.
Taken together, the FOA is best understood as a center-scale, technology-and-infrastructure-driven program with a strong deliverables mindset: build scalable synapse-resolution connectivity mapping capabilities in mice, prove they work in a defined brain region by testing structure-function hypotheses, create usable pipelines and community-facing resources, and coordinate tightly with other awardees to push the field toward standardized, whole-brain wiring diagrams across scales.Apply for RFA NS 22 048
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Comprehensive Centers for Mouse Brain (UM1 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-02-22.
- Applicants must submit their applications by 2023-06-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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